Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy
نویسندگان
چکیده
منابع مشابه
Combining Oncolytic Virotherapy with p53 Tumor Suppressor Gene Therapy
Oncolytic virus (OV) therapy utilizes replication-competent viruses to kill cancer cells, leaving non-malignant cells unharmed. With the first U.S. Food and Drug Administration-approved OV, dozens of clinical trials ongoing, and an abundance of translational research in the field, OV therapy is poised to be one of the leading treatments for cancer. A number of recombinant OVs expressing a trans...
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Histone deacetylase (HDAC) enzymes play a critical role in the epigenetic regulation of cellular functions and signaling pathways in many cancers. HDAC inhibitors (HDACi) have been validated for single use or in combination with other drugs in oncologic therapeutics. An even more novel combination therapy with HDACi is to use them with an oncolytic virus. HDACi may lead to an amplification of t...
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ژورنال
عنوان ژورنال: Molecular Therapy - Oncolytics
سال: 2017
ISSN: 2372-7705
DOI: 10.1016/j.omto.2017.03.002